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Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
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JoVE Journal Medicine
Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

DOI:
10.3791/57452-v

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09:18 min

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July 16, 2018

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, , ,
1Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy,University of North Carolina at Chapel Hill, 2Lineberger Comprehensive Cancer Center,University of North Carolina at Chapel Hill

Chapters

  • 00:04Title
  • 01:06Cell Culture and Scaffold Preparation
  • 04:27Fluorescence-Guided Resection and Scaffold Implantation
  • 07:35Results: Representative Images of Fluorescent Cancer Cells and MSCs Seeded on Resorbable Electrospun Nanofibrous Poly(Lactic Acid)
  • 08:36Conclusion

Summary

Automatic Translation

Automatic Translation

Tumor-seeking therapeutic mesenchymal stem cells (MSCs) show promise as a treatment for invasive glioblastoma. Optimal transplantation involves delivery of MSCs into the tumor resection cavity on scaffolds. Here, preclinical techniques to study MSC treatment of glioblastoma are provided including: image-guided tumor resection; implantation of MSC-seeded scaffolds; and postoperative therapy tracking.

Tags

Keywords: Image-guided ResectionGlioblastomaIntracranial ImplantationTherapeutic Stem CellScaffoldCell TherapyNeuro-oncologySurgical ResectionScaffold-based DeliveryPLA ScaffoldMesenchymal Stem Cells (MSCs)Cell Seeding

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