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Neuroscience
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新化合物调制伽玛-丁酸受体 a 型神经传递的发现方法
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal
Neuroscience
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Please note that all translations are automatically generated.
Click here for the English version.
新化合物调制伽玛-丁酸受体 a 型神经传递的发现方法
DOI:
10.3791/57842-v
•
07:16 min
•
August 16, 2018
•
Frédéric Knoflach
,
Maria-Clemencia Hernandez
,
Daniel Bertrand
1
Discovery Neuroscience, Pharma Research and Early Development
,
Roche Innovation Center Basel
,
2
HiQScreen Sàrl 6
Chapters
00:04
Title
00:54
Receptor Expression and Recordings in
Xenopus Oocytes
02:16
Electrophysiological Recordings in Rat Brain Slices
05:39
Results: A GABA
A
NAM Reduces Paired-pulse Inhibition in Hippocampal Slices
06:49
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
在这里, 我们提出的协议, 以发现活性化合物在 GABA
A
受体, 从绑定到生理学和药理学。
Tags
GABA-A Receptor
Radioligand Binding
Electrophysiology
Xenopus Oocytes
Rodent Brain Slices
Compound Screening
Subtype Selectivity
Efficacy
Microinjection
Voltage Clamp
Population Spike Recording
Hippocampus
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