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JoVE Journal
Bioengineering

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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
 

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

Article DOI: 10.3791/57937
July 16th, 2018

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Summary July 16th, 2018

Proteases are tightly regulated enzymes involved in fundamental biological processes, and dysregulated protease activity drives progression of complex diseases such as cancer. This method's goal is to create nanosensors that measure protease activity in vivo by producing a cleavage signal that is detectable from host urine and discriminates disease.

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