/

Cancer Research

/

抗肿瘤药物对抗癌抗体疗效的潜力: 用组合指数方程检测抗体-药物协同作用

JoVE Journal
Cancer Research
Author Produced

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Cancer Research

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Please note that all translations are automatically generated. Click here for the English version.

抗肿瘤药物对抗癌抗体疗效的潜力: 用组合指数方程检测抗体-药物协同作用

DOI:

10.3791/58291-v

•

15:04 min

•

January 19, 2019

•

Meriem Bahri*¹, Julien Fleurence*¹, Sébastien Faraj*^1,2, Mohamed Ben Mostefa Daho*¹, Sophie Fougeray*^1,3, Stéphane Birklé*^1,3

¹Centre de Recherche en Cancérologie et Immunologie Nantes Angers (CRCINA), Institut national de la santé et de la recherche médicale (INSERM), Université d’Angers, Université de Nantes, Nantes, France, ²Service de chirurgie pédiatrique,Centre hospitalier universitaire (CHU) de Nantes, Nantes, France, ³Unité de Formation et Recherche (UFR) des Sciences Pharmaceutiques et Biologiques,Université de Nantes, Nantes, France

Chapters

00:00Title
01:38Evaluation of the Drug Interaction between mAb 8B6 and Topotecan in vitro
07:35Generation of Human IMR5 Neuroblastoma Xenografts in NSG Mice
12:18Representative Results
14:09Conclusion

Summary

Automatic Translation

该方案介绍了如何利用周药和塔拉莱的组合指数方程来评价临床前模型中抗癌抗体与抗肿瘤药物之间的协同作用。

Tags

Anticancer Antibody Antineoplastic Drugs Combination Index Synergism Immunotherapy Chemotherapy Monoclonal Antibody Neuroblastoma Topotecan In Vitro In Vivo Cell Culture Xenograft Model

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

胰腺癌的荧光原位小鼠模型

光动力疗法的抗癌功效肺癌靶向纳米粒子

二维凝胶电泳结合质谱法分析人垂体腺瘤组织蛋白质组

流式细胞术对小鼠原发性胰腺导管腺癌原位同种异体 (自体) 免疫分型的研究

球体、菌落形成测定和斑马鱼移植对抗癌香豆素 OT48 生物活性的临床前评价

用抗体阵列对信号转导通路的审问对酪氨酸激酶抑制剂的抗性评价

荧光肽酶谱法检测蛋白酶活性

使用一套实用可行的方法,描述英国皇家空军家族激酶与疾病相关的突变体

长距离反向PCR对热线1的逆变活性的检测

使用锚定多路聚合酶链反应的致癌基因融合检测,随后进行下一代测序

Read Article