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压力增强恐惧学习--创伤后应激障碍的健壮啮齿动物模型

JoVE Journal
Behavior

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JoVE Journal Behavior

Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

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压力增强恐惧学习--创伤后应激障碍的健壮啮齿动物模型

DOI:

10.3791/58306-v

•

05:49 min

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October 13, 2018

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Abha K. Rajbhandari², Sarah T. Gonzalez², Michael S. Fanselow^2,3

¹Department of Psychology,University of California, Los Angeles, ²Staglin Center for Brain and Behavioral Health,University of California, Los Angeles, ³Department of Psychiatry and Biobehavioral Sciences,University of California, Los Angeles

Chapters

00:04Title
00:33Experimental Setup
01:48SEFL Procedure
04:41Results: Trauma Animals Show High Levels of Freezing and Lower Shock Reactivity Compared to Controls
05:26Conclusion

Summary

Automatic Translation

在这里, 我们描述了进行压力增强恐惧学习 (大我) 实验所需的详细方法, 这是在大鼠和小鼠创伤后应激障碍的临床前模型。该模型利用巴甫洛夫恐惧调理和冻结的各个方面作为对啮齿动物增强恐惧的指标。

Tags

Stress-enhanced Fear Learning PTSD Model Rodent Model Fear Conditioning Context A Context B Foot Shock Shock Generator Scrambler Grid Floor Plexiglass Insert Trauma Conditioning

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