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Biology

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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
 

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Article doi: 10.3791/58439
January 7th, 2019 Usage Statistics

Summary January 7th, 2019

MALT1 regulates innate immunity but how this occurs remains ill-defined. We used the selective MALT1 paracaspase inhibitor MLT-827 to unravel the contribution of MALT1 to innate signaling downstream of Toll-like or C-type lectin-like receptors, demonstrating that MALT1 regulates the production of myeloid cytokines, and downstream of C-type lectin-like receptors, selectively.

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