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Chapters
- 00:04Title
- 00:51Preparation of Peripheral Blood Mononuclear Cells (PBMCs) from Human Buffy Coats
- 02:48PBMCs Treatments and Stimulatory Conditions
- 03:45Compound Preparation
- 04:20Stimuli Preparation
- 04:42Results: Signaling Pathway Regulation by MALT1 Paracaspase Activity
- 06:40Conclusion
MALT1 regulerer medfødt immunitet, men hvor dette sker fortsat er uklare. Vi brugte den selektive MALT1 paracaspase hæmmer MLT-827 for at trævle MALT1 bidrag til medfødte signalering neden for Toll-lignende eller C-type lektin-lignende receptorer, demonstrerer, at MALT1 regulerer produktionen af myeloide cytokiner, og downstream af C-typen lektin-lignende receptorer selektivt.
