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Simultaneous Electrical and Mechanical Stimulation to Enhance Cells’ Cardiomyogenic Potential
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1Insuficiencia Cardiaca y Regeneración Cardiaca (ICREC) Research Program,Health Science Research Institute Germans Trias i Pujol, 2Amsterdam Universitair Medisch Centrum (UMC), Vrije Universiteit Amsterdam, Pulmonology and Physiology,Amsterdam Cardiovascular Sciences, 3Electronic and Biomedical Instrumentation Group, Departament d’Enginyeria Electrònica,Universitat Politècnica de Catalunya, 4Cardiology Service,Germans Trias i Pujol University Hospital, 5Department of Medicine,Universitat Autònoma de Barcelona, 6Centro de Investigación Biomédica en Red (CIBER) Cardiovascular,Instituto de Salud Carlos III
Chapters
- 00:04Title
- 01:06Cell Seeding (Day – 1)
- 02:52Electromechanical Stimulation Setup (Day 0)
- 05:55Results: Gene and Protein Expression of the Main Cardiac Markers after the Electromechanical Stimulation of Cardiac and Subcutaneous ATDPCs
- 07:08Conclusion
Here we present a protocol for training a cell population using electrical and mechanical stimuli emulating cardiac physiology. This electromechanical stimulation enhances the cardiomyogenic potential of the treated cells and is a promising strategy for further cell therapy, disease modeling, and drug screening.
