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Journal / Genetics / Utredning av den transkriptionella roll som en…
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Genetics

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JoVE Journal Genetics
Utredning av den transkriptionella roll som en RUNX1 Intronic ljuddämpare av CRISPR/Cas9 Ribonucleoprotein i akut myeloisk leukemi celler
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Utredning av den transkriptionella roll som en RUNX1 Intronic ljuddämpare av CRISPR/Cas9 Ribonucleoprotein i akut myeloisk leukemi celler

Article DOI: 10.3791/60130-v • 09:16 min • September 1st, 2019
September 1st, 2019 •
1, 1, 1, 1, 1,2
1Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, 2State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong

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Direktleverans av förmonterade Cas9/guide RNA ribonukleoprotein komplex är ett snabbt och effektivt sätt för genomredigering i hematopoietiska celler. Här använder vi denna metod för att ta bort en RUNX1 intronic ljuddämpare och undersöka transkriptionella svaren i OCI-AML3 leukemi celler.

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Genetik CRISPR/CAS9 ribonucleoprotein elektroporation CIS-reglerande element ljuddämpare transkriptionell kontroll leukemi
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