A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Department of Surgery, Division of Vascular Surgery,University of North Carolina at Chapel Hill, 2Center for Nanotechnology in Drug Delivery,University of North Carolina at Chapel Hill, 3Curriculum in Toxicology & Environmental Medicine,University of North Carolina at Chapel Hill, 4Department of Cell Biology & Physiology,University of North Carolina at Chapel Hill, 5McAllister Heart Institute,University of North Carolina at Chapel Hill
Chapters
- 00:05Introduction
- 00:47Common Carotid Artery (CCA) Identification
- 02:16CCA Dissection
- 03:29Carotid Artery Pressure-Controlled Segmental Balloon Injury
- 05:36Results: Representative Hematoxylin & Eosin (H&E) and Light Sheet Fluorescence Microscopy Imaging
- 06:19Conclusion
La lesión del globo arterial carótido de rata imita el procedimiento clínico de angioplastia realizado para restaurar el flujo sanguíneo en vasos ateroscleróticos. Este modelo induce la respuesta a lesiones arteriales al desprestir la pared arterial, y desnudar la capa intimal de las células endoteliales, causando en última instancia remodelación y una respuesta hiperplástica intimal.
