Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Dmitry Frank; Benjamin  F. Gruenbaum; Julia Grinshpun; Israel Melamed; Olena Severynovska; Ruslan Kuts; Michael Semyonov; Evgeni Brotfain; Alexander Zlotnik; Matthew Boyko

doi:10.3791/61309

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Måling av post-stroke cerebralt ødem, infarktsone og blod-hjernebarrieresammenbrudd i ett enkelt sett med gnagerhjerneprøver

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Måling av post-stroke cerebralt ødem, infarktsone og blod-hjernebarrieresammenbrudd i ett enkelt sett med gnagerhjerneprøver

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7,882 Views

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04:32 min

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October 23, 2020

DOI:

10.3791/61309-v

DOI:

10.3791/61309-v

•

04:32 min

October 23, 2020

•

7869 Views

Dmitry Frank*¹, Benjamin F. Gruenbaum*², Julia Grinshpun¹, Israel Melamed³, Olena Severynovska⁴, Ruslan Kuts¹, Michael Semyonov¹, Evgeni Brotfain¹, Alexander Zlotnik¹, Matthew Boyko¹

¹Department of Anesthesiology and Critical Care, Soroka Medical Center,Ben-Gurion University of the Negev ²Department of Anesthesiology,Yale University School of Medicine ³Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences,Ben-Gurion University of the Negev ⁴Department of Physiology, Faculty of Biology, Ecology and Medicine,Dnepropetrovsk State University

Summary

Denne protokollen beskriver en ny teknikk for å måle de tre viktigste parametrene for iskemisk hjerneskade på samme sett med gnagerhjerneprøver. Bruk av bare én hjerneprøve er svært fordelaktig når det gjelder etiske og økonomiske kostnader.