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En model af Epileptogenese i Rhinal Cortex-Hippocampus Organotypic Slice Cultures
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

En model af Epileptogenese i Rhinal Cortex-Hippocampus Organotypic Slice Cultures

English

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6,484 Views

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10:05 min

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March 18, 2021

DOI:

10.3791/61330-v

DOI:
10.3791/61330-v

•

10:05 min
March 18, 2021

•

7 Views
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1Instituto de Farmacologia e Neurociências,Faculdade de Medicina da Universidade de Lisboa, 2Instituto de Medicina Molecular João Lobo Antunes,Faculdade de Medicina da Universidade de Lisboa

Summary

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Her beskriver vi forberedelsen af rhinal cortex-hippocampus organotypic skiver. Under en gradvis og kontrolleret afsavn af serum skildrer disse skiver udviklende epileptiske-lignende begivenheder og kan betragtes som en ex vivo-model af epileptogenese. Dette system repræsenterer et glimrende værktøj til overvågning af dynamikken i spontan aktivitet samt til vurdering af udviklingen af neuroinflammatoriske træk i løbet af epileptogenese.

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Valente, C. A., Meda, F. J., Carvalho, M., Sebastião, A. M. A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures. J. Vis. Exp. (169), e61330, doi:10.3791/61330 (2021).

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