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Neuroscience

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In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
 

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity

Article DOI: 10.3791/61664
August 18th, 2020

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Summary August 18th, 2020

Integration of diverse synaptic inputs to neurons is best measured in a preparation that preserves all pre-synaptic nuclei for natural timing and circuit plasticity, but brain slices typically sever many connections. We developed a modified brain slice to mimic in vivo circuit activity while maintaining in vitro experimentation capability.

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