A Murine Tail Lymphedema Model

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Medicine

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Medicine

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JoVE Journal Medicine

A Murine Tail Lymphedema Model

DOI:

10.3791/61848-v

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04:38 min

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February 10, 2021

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Aladdin H. Hassanein*¹, Mithun Sinha*¹, Colby R. Neumann, Ganesh Mohan, Imran Khan, Chandan K. Sen

¹Department of Surgery, Indiana Center for Regenerative Medicine and Engineering,Indiana University School of Medicine

Chapters

00:04Introduction
00:53Surgical Disruption of Mouse Tail Lymphatics
02:33Functional Lymphatic Evaluation with Near Infrared Laser Angiography
02:54Result: Assessment of Progressive Swelling, Lymphatic Function, and Focal Delivery of Genetic Cargo in the Mouse Tail Lymphedema Model
04:09Conclusion

Summary

Automatic Translation

Lymphedema is extremity swelling caused by lymphatic dysfunction. We describe a chronic murine tail model of lymphedema and the novel use of tissue nanotransfection technology (TNT) for genetic cargo delivery to the tail.

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