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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

DOI:
10.3791/61865-v

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05:20 min

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November 12, 2020

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, , , , , ,
1Laboratory of Photobiology,Keio University School of Medicine, 2Department of Ophthalmology,Keio University School of Medicine, 3Animal eye care,Tokyo Animal Eye Clinic, 4Tsubota Laboratory, Inc.

Chapters

  • 00:04Introduction
  • 01:00Transient Bilateral Common Carotid Artery Occlusion (tBCCAO)
  • 03:12Results: Analysis of Eyelid Drooping, HIF-1α Stabilization, Reactive Gliosis, Visual Dysfunction, and Change in Retinal Thickness After tBCCAO
  • 04:40Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we describe a mouse model of retinal ischemia by transient bilateral common carotid artery occlusion using simple sutures and a clamp. This model can be useful for understanding the pathological mechanisms of retinal ischemia caused by cardiovascular abnormalities.

Tags

Ischemic Retinal InjuryTransient Bilateral Common Carotid Artery OcclusionMurine ModelRetinal IschemiaPathophysiologyIschemic RetinopathiesIn Vivo Drug ScreeningVascular DiseasesDiabetic RetinopathyOcclusion Of Retinal Veins Or ArteriesOcular Ischemic SyndromeBALB/c MiceEyelid Drooping

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