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Bioengineering
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3D 细胞打印的芯片上低氧癌症,用于回顾固体癌症的病理进展
JoVE Journal
Bioengineering
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JoVE Journal
Bioengineering
3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer
Please note that all translations are automatically generated.
Click here for the English version.
3D 细胞打印的芯片上低氧癌症,用于回顾固体癌症的病理进展
DOI:
10.3791/61945-v
•
10:51 min
•
January 05, 2021
•
Wonbin Park*
1
,
Mihyeon Bae*
1
,
Minseon Hwang
,
Jinah Jang
,
Dong-Woo Cho
,
Hee-Gyeong Yi
3
1
Department of Mechanical Engineering
,
Pohang University of Science and Technology (POSTECH)
,
2
Department of Creative IT Engineering
,
Pohang University of Science and Technology (POSTECH)
,
3
Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences
,
Chonnam National University
Chapters
00:05
Introduction
00:56
Collagen Pre-Gel Solution Preparation
01:47
1% Neutralized Collagen Pre-Gel Solution pH Adjustment
03:12
Gas-Permeable Barrier 3D Printing
04:20
Polydimethylsiloxane (PDMS) Barrier Casting
05:29
1% Neutralized Collagen Pre-Gel Solution Cell Mixing
06:19
Cancer-Stroma Concentric Ring 3D Cell Printing
07:39
Hypoxic Cancer-on-a-Chip Maintenance
08:11
Results: Representative Solid Pathologic Cancer Progression on a 3D Cell-Printed Hypoxic Cancer-on-a-Chip
10:06
Conclusion
Summary
Automatic Translation
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Automatic Translation
缺氧是肿瘤微环境的标志,在癌症进展中起着至关重要的作用。本文描述了基于3D细胞打印技术的芯片上低氧癌症的制造过程,以回顾癌症的缺氧相关病理学。
Tags
3D Cell Printing
Hypoxic Cancer
Cancer-on-a-chip
Solid Cancer
Pathologic Progression
3D Bioprinting
Radio Hypoxic Gradient
Drug Efficacy
Patient-specific Anticancer Drug
Aggressive Cancer Diagnosis
Collagen Pre-gel Solution
PEVA Mold
3D CAD File
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