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Risposta cardiaca alla stimolazione β-adrenergica determinata dall'analisi del ciclo pressione-volume
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Risposta cardiaca alla stimolazione β-adrenergica determinata dall'analisi del ciclo pressione-volume

Article DOI: 10.3791/62057-v • 08:05 min • May 19th, 2021
May 19th, 2021 •
*1,2, *1,2,3, *1,2,4, 1,2, 1,2
1Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, 2DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, 3Department of Internal Medicine III, University of Heidelberg, 4Department of Anesthesiology, University Hospital RWTH Aachen
* These authors contributed equally

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Qui descriviamo un'analisi del ciclo pressione-volume cardiaco sotto dosi crescenti di isoproterenolo infuso per via endovenosa per determinare la funzione cardiaca intrinseca e la riserva β-adrenergica nei topi. Utilizziamo un approccio a cassa aperta modificato per le misurazioni del ciclo pressione-volume, in cui includiamo la ventilazione con pressione positiva di fine espirazione.

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Medicina Numero 171 β-adrenergica isoproterenolo funzione cardiaca Loop pressione-volume cuore topo in vivo petto aperto
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