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Cancer Research

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JoVE Journal Cancer Research
Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
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Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Article DOI: 10.3791/62457-v • 09:27 min • April 1st, 2021
April 1st, 2021 •
1,2, 1,2, 1,2,3,4
1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 2Department of Medicine (Hepatology), Albert Einstein College of Medicine, 3Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, 4Marion Bessin Liver Research Center, Albert Einstein College of Medicine

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Summary
Automatic Translation

Here, we present how to generate a non-alcoholic fatty liver disease (NAFLD)-associated Hepatocellular Carcinoma (HCC) zebrafish model to study the impact of cholesterol surplus on liver microenvironment and immune cell landscape.

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Liver Microenvironment Non-alcoholic Fatty Liver Disease-associated Hepatocellular Carcinoma Zebrafish Intravital Microscopy Immune Landscape Transparency Diet-induced Nephrotic Model Cell-cell Interactions Metabolic Syndrome Cardiovascular Diseases Lab Technician Postdoctoral Fellow Commercial Dry Food Diet High Cholesterol Diet (HCD) Diethyl Ether
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