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1Global Drug Discovery,Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik
Chapters
- 00:05Introduction
- 01:10Beginning of the Experiment
- 02:00Performing Tail Vein Transection
- 02:46Observation Time and Challenges
- 03:49Treatment of Samples
- 04:33Results: Effect of rFVIII After Intravenous Administration
- 07:29Conclusion
Den raffinerte hale vene transeksjon (TVT) blødning modell i bedøvede mus er en sensitiv in vivo metode for vurdering av hemofil blødning. Denne optimaliserte TVT blødningsmodellen bruker blodtap og blødningstid som endepunkter, raffinerer andre modeller og unngår døden som endepunkt.
