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Journal / Genetics / 利用小鼠模型研究MYH7突变Gly823Glu在家族性肥厚型心肌病中的发病机制…
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Genetics

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JoVE Journal Genetics
利用小鼠模型研究MYH7突变Gly823Glu在家族性肥厚型心肌病中的发病机制
Transcription Start Site Mapping Using Super-low Input Carrier-CAGE
Journal (Genetics)
Transcription Start Site Mapping Using Super-low Input Carrier-CAGE
Using a Fluorescent PCR-capillary Gel Electrophoresis Technique to Genotype CRISPR/Cas9-mediated Knockout Mutants in a High-throughput Format
Journal (Genetics)
Using a Fluorescent PCR-capillary Gel Electrophoresis Technique to Genotype CRISPR/Cas9-mediated Knockout Mutants in a High-throughput Format
 
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利用小鼠模型研究MYH7突变Gly823Glu在家族性肥厚型心肌病中的发病机制

Article DOI: 10.3791/63949-v • 03:45 min • August 8th, 2022
August 8th, 2022 •
*1,2, *3, 4, 4, 1,2, 1,2, 1,2, 2,5, 4, 1,2
1Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 2The Second Clinical College of Guangzhou University of Chinese Medicine, 3Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, 4Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 5Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
* These authors contributed equally

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基于我们临床工作中发现的家族性遗传性心肌病家族，我们通过CRISPR / Cas9介导的基因组工程在小鼠MYH7位点创建了一个具有点突变（G823E）的C57BL / 6N小鼠模型来验证该突变。

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遗传学，第186期，
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