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Journal / Genetics / 마우스 모델을 사용한 가족성 비후성 심근병증에서 MYH7 돌연변이 Gly823Glu의…
JoVE Journal
Genetics

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JoVE Journal Genetics
마우스 모델을 사용한 가족성 비후성 심근병증에서 MYH7 돌연변이 Gly823Glu의 발병기전 조사
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마우스 모델을 사용한 가족성 비후성 심근병증에서 MYH7 돌연변이 Gly823Glu의 발병기전 조사

Article DOI: 10.3791/63949-v • 03:45 min • August 8th, 2022
August 8th, 2022 •
*1,2, *3, 4, 4, 1,2, 1,2, 1,2, 2,5, 4, 1,2
1Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 2The Second Clinical College of Guangzhou University of Chinese Medicine, 3Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, 4Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 5Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
* These authors contributed equally

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임상 연구에서 발견된 가족성 유전성 심근병증 계열을 기반으로 이 돌연변이를 확인하기 위해 CRISPR/Cas9 매개 게놈 엔지니어링을 통해 마우스 MYH7 유전자좌에서 점 돌연변이(G823E)가 있는 C57BL/6N 마우스 모델을 만들었습니다.

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