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Journal / Genetics / Studio della patogenesi della mutazione MYH7…
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JoVE Journal Genetics
Studio della patogenesi della mutazione MYH7 Gly823Glu nella cardiomiopatia ipertrofica familiare utilizzando un modello murino
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Studio della patogenesi della mutazione MYH7 Gly823Glu nella cardiomiopatia ipertrofica familiare utilizzando un modello murino

Article DOI: 10.3791/63949-v • 03:45 min • August 8th, 2022
August 8th, 2022 •
*1,2, *3, 4, 4, 1,2, 1,2, 1,2, 2,5, 4, 1,2
1Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 2The Second Clinical College of Guangzhou University of Chinese Medicine, 3Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, 4Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 5Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
* These authors contributed equally

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Sulla base della famiglia di cardiomiopatie ereditarie familiari trovata nel nostro lavoro clinico, abbiamo creato un modello murino C57BL / 6N con una mutazione puntiforme (G823E) nel locus MYH7 del topo attraverso l'ingegneria del genoma mediata da CRISPR / Cas9 per verificare questa mutazione.

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Genetica Numero 186
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