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Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection

Article DOI: 10.3791/64048-v • 08:23 min • May 9th, 2022
May 9th, 2022 •
1, 1, 2,3, 1, 2,3, 4, 2,3, 1, 5, 1, 1, 3,6, 1,7, 2,3, 1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Neurosurgery, University of Maryland School of Medicine, 3Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, 4Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 5Pontifical Catholic University of Parana, 6Department of Pathology, University of Maryland School of Medicine, 7Departments of Ophthalmology, Oncology and Biomedical Engineering, Johns Hopkins University School of Medicine

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Summary
Automatic Translation

The present protocol describes a standardized resection of brain tumors in rodents through a minimally invasive approach with an integrated tissue preservation system. This technique has implications for accurately mirroring the standard of care in rodent and other animal models.

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Minimally Invasive Brain Tumor Resection Rodents High Viability Tissue Collection Preclinical Research Therapeutics Standardized Resection Minimally-invasive Approach Automated Tissue Preservation System Disease State Therapy Animal Survival Sequential And Time-lapse Therapeutic Applications Biology Of The Disease Drug Discovery Novel Therapeutics Liver Tumors Head And Neck Cancers User-friendly System Published Protocol Sedation Assessment Ophthalmic Ointment Stereotactic Frame Disinfecting The Skin
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