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Venstre koronararterieligering: En kirurgisk murinmodel af myokardieinfarkt
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JoVE Journal Medicine
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Venstre koronararterieligering: En kirurgisk murinmodel af myokardieinfarkt

DOI:
10.3791/64387-v

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05:48 min

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August 09, 2022

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,
1Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine,University of Pittsburgh, 2Department of Immunology,University of Pittsburgh, 3Department of Bioengineering, Swanson School of Engineering,University of Pittsburgh

Chapters

  • 00:05Introduction
  • 00:35Preparation and Endotracheal Intubation of the Mice
  • 02:23Permanent Ligation of the Left Coronary Artery
  • 03:51Post-Operative Care
  • 04:22Results: A Reproducible and Clinically Relevant Myocardial Infarction Murine Model to Improve the Left Coronary Artery Ligation
  • 05:19Conclusion

Summary

Automatic Translation

Automatic Translation

Præsenteret her er en kirurgisk procedure for permanent ligering af venstre koronararterie hos mus. Denne model kan bruges til at undersøge patofysiologien og tilhørende inflammatorisk respons efter myokardieinfarkt.

Tags

Keywords: Left Coronary Artery LigationSurgical Murine ModelMyocardial InfarctionMouse ModelMIAnesthesiaBuprenorphineIntubationVentilatorThoracotomyLeft VentricleLeft Coronary Artery

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