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Utvikling av et 68galliummerket D-peptid PET-tracer for avbildning programmert død-ligand 1-uttrykk

Article DOI: 10.3791/65047-v • 09:06 min • February 3rd, 2023
February 3rd, 2023 •
*1, *2, 1, 2, 2, 4, *2,3, *3, *1, *2
1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
* These authors contributed equally

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Denne studien utviklet en ikke-invasiv og sanntidsmetode for å evaluere fordelingen av programmert dødsligand 1 i hele kroppen, basert på positronemisjons tomografisk avbildning av [68Ga] D-dodekapeptidantagonist. Denne teknikken har fordeler i forhold til konvensjonell immunhistokjemi og forbedrer effektiviteten ved å identifisere passende pasienter som vil ha nytte av immunkontrollpunktblokkadebehandling.

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Kreftforskning utgave 192 programmert dødsligand 1-uttrykk immunkontrollpunktblokkadeterapi PD-1 PD-L1-hemmere tumorceller immunhistokjemi (IHC) positronemisjonstomografi (PET) radiomerkede sporstoffer dekstrorotære (D)-peptider proteolytisk resistens metabolske halveringstider 68Ga-merket PD-L1-målrettet D-peptid D-dodekapeptidantagonist (DPA) tumorbærende mus stabilitet bildeevne
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