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Chapters
- 00:05Title
- 01:52Placement of Femoral Arterial and Venous Catheters
- 03:20Establish Mechanical Ventilation
- 04:12Placement of Flow Probes at Superior Mesenteric and Left Renal Arteries
- 07:13Hypoxia and Reoxygenation Protocol
- 08:48Typical Changes in Hemodynamic Parameters During Hypoxia
- 09:57Conclusion
Large animal models have good translational values in the examination of physiology and pharmacology of neonatal asphyxia. Using newborn piglets, we develop an experimental protocol to simulate neonatal asphyxia which has advantages of studying the systemic and regional hemodynamics, oxygen transport with biochemical and pathologic pathways and correlations.
Tags
Swine ModelNeonatal AsphyxiaMulti-organ FailureHypotensionPerfusion DeficitHypoxic-ischemic EncephalopathyPulmonary HypertensionVasculopathic EnterocolitisRenal FailureThrombo-embolic ComplicationsAnimal ModelsPatho-physiologyPharmacologyNewborn PigletBody SystemsHemodynamic ChangesInterventionsMulti-organ FailureDysfunctionSurgical InstrumentationMechanical VentilationVascular
