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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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Bioengineering
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JoVE Journal Bioengineering
High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

DOI:
10.3791/3967-v

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14:37 min

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July 06, 2012

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, , , ,
1Department of Chemical and Biological Engineering,Iowa State University, 2Department of Chemistry,Iowa State University

Chapters

  • 00:05Title
  • 02:01High-throughput Carbohydrate Synthesis
  • 06:37High-throughout Nanoparticle Surface Functionalization
  • 11:50Representative Results
  • 13:37Conclusion

Summary

Automatic Translation

Automatic Translation

In this article, a high throughput method is presented for the synthesis of oligosaccharides and their attachment to the surface of polyanhydride nanoparticles for further use in targeting specific receptors on antigen presenting cells.

Tags

High-throughput SynthesisCarbohydratesFunctionalizationPolyanhydride NanoparticlesMaterial DesignNanotechnologyChemistryImmunologyVaccine CarriersNanoparticle-based PlatformsVaccine AntigensBiodegradable PolymersVaccine Delivery VehiclesSustained ReleaseProtein AntigensAntigen Presenting CellsImmune ResponsesMolecular DesignPolymer PropertiesTargeting AgentsHigh Throughput Automated FabricationTargeting LigandsFunctionalized ParticlesReproducible Vaccine Delivery DevicesSpecific ReceptorsImmune CellsC-type Lectin Receptors (CLRs)Pattern Recognition Receptors (PRRs)Carbohydrates

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