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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
JoVE Journal
Medicine
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JoVE Journal Medicine
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
DOI:

10:03 min

February 28, 2013

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Chapters

  • 00:05Title
  • 01:51Generation of Zebrafish with Diabetes Mellitus
  • 04:26Blood Collection and Fasting Blood Glucose Level (FBGL) Determination
  • 05:51Caudil Fin Regeneration
  • 07:17Generation of Metabolic Memory Zebrafish
  • 08:46Representative Fin Regeneration Results
  • 09:38Conclusion

Summary

Automatic Translation

Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.

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