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A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
JoVE Journal
Medicine
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JoVE Journal Medicine
A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
DOI:

08:32 min

June 27, 2018

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Chapters

  • 00:04Title
  • 00:36Preparation of the Portal Vein Cuff and Bile Duct Cannula
  • 01:20Liver Procurement Procedure
  • 05:24Ex Vivo Normothermic Liver Perfusion
  • 06:58Results: Analysis of Tissue Damage in Base Perfusate-only and Base Perfusate and Plus PEG-CAT Groups
  • 07:56Conclusion

Summary

Automatic Translation

There is a significant liver donor shortage, and criteria for liver donors have been expanded. Normothermic ex vivo liver perfusion (NEVLP) has been developed to evaluate and modify organ function. This study demonstrates a rat model of NEVLP and tests the ability of pegylated-catalase, to mitigate liver preservation injury.

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