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Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
DOI:

10:08 min

June 08, 2018

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Chapters

  • 00:04Title
  • 00:57Striatum, Hippocampus, and Cortex Harvest: Technique 1
  • 03:15Striatum, Hippocampus, and Cortex Harvest: Technique 2
  • 04:33Generation of Single Cell Suspensions
  • 06:01P0-2 Wild-Type (WT) Pup Transplantation
  • 08:13Results: Representative Grafted Interneuron Analyses
  • 09:28Conclusion

Summary

Automatic Translation

Challenging young neurons in new brain regions can reveal important insights into how the environment sculpts neuronal fate and maturation. This protocol describes a procedure to harvest interneuron precursors from specific brain regions and transplant them either homotopically or heterotopically into the brain of postnatal pups.

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