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Assessment of Kidney Function in Mouse Models of Glomerular Disease
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Assessment of Kidney Function in Mouse Models of Glomerular Disease
DOI:

09:16 min

June 30, 2018

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Chapters

  • 00:04Title
  • 00:30Sample Collection and Preparation for Analysis
  • 03:27Glomeruli Isolation and Glomerular Water Permeability (LpA/Vi)
  • 05:36Periodic Acid Schiff (PAS) Stain
  • 06:55Results: Representative Kidney Function Assessment
  • 08:55Conclusion

Summary

Automatic Translation

This protocol describes a full kidney work-up that should be carried out in mouse models of glomerular disease. The methods allow for detailed functional, structural, and mechanistic analysis of glomerular function, which can be applied to all mouse models of glomerular disease.

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