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18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
JoVE Journal
Chemistry
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JoVE Journal Chemistry
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
DOI:

09:57 min

January 11, 2020

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Chapters

  • 00:00Title
  • 04:27Azeotropic Drying of F-18 Anion
  • 06:28One Step SiFA-Ligand Labelling
  • 08:19Results
  • 09:07Conclusion

Summary

Automatic Translation

The synthesis of fluorine-18 (18F) labeled radiopharmaceuticals for positron emission tomography typically requires months of experience. When incorporated into a radiotracer, the silicon-fluoride acceptor (SiFA) motif enables a simple 18F-labeling protocol that is independent of costly equipment and preparatory training, while reducing precursor quantity needed and utilizing milder reaction conditions.

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