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Journal / Cancer Research / Li-Fraumeni sendromu hasta kaynaklı indüklenmiş…
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JoVE Journal Cancer Research
Li-Fraumeni sendromu hasta kaynaklı indüklenmiş Pluripotent kök hücreler kullanılarak osteosarkom modelleme
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Li-Fraumeni sendromu hasta kaynaklı indüklenmiş Pluripotent kök hücreler kullanılarak osteosarkom modelleme

Article DOI: 10.3791/57664-v • 08:52 min • June 13th, 2018
June 13th, 2018 •
1,2, 1, 1,3, 1, 4, 1, 1,2,5,6
1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, 2Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth, 3Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, 4Women's Health Institute, Cleveland Clinic Foundation, 5Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, 6Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston

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Burada, bir protokol indüklenmiş pluripotent kök hücreler (iPSCs) üretimi için Li-Fraumeni sendromu (LFS) hasta türetilmiş fibroblastlar, iPSCs mezenkimal kök hücre (MSCs) yoluyla farklılaşma üzerinden dokusunu ve modelleme içinde vivo mevcut LFS hasta kaynaklı dokusunu kullanarak tumorigenesis.

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Kanser Araştırmaları sayı: 136 iPSCs Li-Fraumeni sendromu yeniden programlama farklılaşma mezenkimal kök hücre dokusunu osteosarkom xenograft
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