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JoVE Journal
Biology

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The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF
 
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The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF

Article DOI: 10.3791/1550
November 18th, 2009

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Summary November 18th, 2009

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Click here for the English version.

SC1 functions through dual inhibition of Ras- GAP and ERK1. We tested the function of SC1 in supporting mouse ES cell self-renewal in the absence of LIF and showed that SC1 is able to maintain self-renewal of mouse ES cell cultures.

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