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细菌提供的RNAi效应：Transkingdom RNA干扰

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Biology

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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

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细菌提供的RNAi效应：Transkingdom RNA干扰

DOI:

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07:56 min

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August 18, 2010

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Chapters

00:04Title
00:11Introduction
01:23TRIP Vector and Proposed Mech for tkRNAi
02:45Co-incubation of Bacteria and Cancer Cells
05:56Representative Results
07:21Conclusion

Summary

Automatic Translation

RNA干扰（RNAi）技术为基础的疗法的发展，一种新型的战略发展，transkingdom RNA干扰（tkRNAi）。该技术使用非致病性细菌产生并传递到靶细胞治疗短发夹RNA（shRNA）。在这里，tkRNAi成功地应用于古典ABCB1介导的多药耐药（MDR）的癌细胞逆转。

Tags

RNA Interference RNAi Effectors Transkingdom RNAi Therapeutic Utilization RNAi-mediating Agents Escherichia Coli Short Hairpin RNA (shRNA)TRIP Vector Yersinia Pseudotuberculosis Invasin β1-integrin-positive Mammalian Cells Listeria Monocytogenes Listeriolysin O T7 RNA Polymerase ABCB1 (MDR1/P-glycoprotein)

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