A method for developing cell culture substrates with the ability to change topography during culture is described. The method makes use of smart materials known as shape memory polymers that have the ability to memorize a permanent shape. This concept is adaptable to a wide range of materials and applications.
Davis, K. A., Luo, X., Mather, P. T., Henderson, J. H. Shape Memory Polymers for Active Cell Culture. J. Vis. Exp. (53), e2903, doi:10.3791/2903 (2011).