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Bioengineering
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三维人体皮肤重建模型:一种工具来研究正常皮肤恶性黑色素瘤进展
JoVE Journal
Bioengineering
This content is Free Access.
JoVE Journal
Bioengineering
The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
Please note that all translations are automatically generated.
Click here for the English version.
三维人体皮肤重建模型:一种工具来研究正常皮肤恶性黑色素瘤进展
DOI:
10.3791/2937-v
•
11:02 min
•
August 03, 2011
•
Ling Li
,
Mizuho Fukunaga-Kalabis
,
Meenhard Herlyn
1
Molecular and Cellular Oncogenesis Program
,
The Wistar Institute
Chapters
00:05
Title
01:24
Dermal Layer Preparation
03:22
Generation of the Epidermis
05:21
Day 18 Skin Reconstruct Harvesting and Sectioning
07:01
Graft a Skin Reconsruct on a Mouse
08:42
Representative Skin Reconstructs of Normal Melanocytes, Dermal Stem Cells and Melanoma Tumors
10:43
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
在这份报告中,我们描述了皮肤三维重建模型模仿人体皮肤结构和组成。使用皮肤重建模型被查处的黑素细胞的生理,黑色素瘤的进展和皮肤干细胞的命运。该模型也可作为临床前药物评估工具。
Tags
Three-dimensional Human Skin Reconstruct Model
In Vitro Studies
Experimental Skin Biology
2-dimensional Monocultures
3D Extra-cellular Matrix
Cell-cell Interactions
Mouse Models
Cellular Architecture
Physiology
Melanocytes
Hair Follicles
Basal Layer Of The Epidermis
3D Human Skin Reconstruct Models
Dermis
Fibroblasts
Collagen I Matrix
Epidermis
Stratified Differentiated Keratinocytes
Functional Basement Membrane
Scaffolding
Nutrient Delivery
Cell-to-cell Interaction
Melanocyte Homeostasis
Melanoma Progression
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