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JoVE Journal
Immunology and Infection

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Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
 
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Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery

Article DOI: 10.3791/2954
June 23rd, 2011

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Summary June 23rd, 2011

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Several 2’-Fluoro RNA aptamers against HIV-1Ba-L gp120 with nanomole affinity are isolated from a RNA library by in vitro SELEX procedure. A new dual inhibitory function anti-gp120 aptamer-siRNA chimera is created and shows considerable promise for systemic anti-HIV therapy.

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