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Medicine
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在小鼠模型
体内
生物发光成像乳腺癌脑转移的肿瘤乏氧动力学
JoVE Journal
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JoVE Journal
Medicine
In vivo
Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model
Please note that all translations are automatically generated.
Click here for the English version.
在小鼠模型
体内
生物发光成像乳腺癌脑转移的肿瘤乏氧动力学
DOI:
10.3791/3175-v
•
11:02 min
•
October 03, 2011
•
Debabrata Saha
,
Henry Dunn
,
Heling Zhou
,
Hiroshi Harada
,
Masahiro Hiraoka
,
Ralph P. Mason
,
Dawen Zhao
1
Department of Radiation Oncology
,
University of Texas Southwestern Medical Center
,
2
Department of Radiology
,
University of Texas Southwestern Medical Center
,
3
Department of Radiation Oncology
,
Kyoto University Graduate School of Medicine
Chapters
00:05
Title
01:46
Validation of MDA-MB231/5HRE-ODD-luc Cells as a Tool for Measuring Hypoxia Dynamics
04:03
Culture of MDA-MB231/5HRE-ODD-luc Cells for Surgical Implantation
04:36
Surgical Implantation of MDA-MB231/5HRE-ODD-luc Cells into the Mouse Brain
06:23
In vivo
Bioluminescence Imaging of Tumor Hypoxia Dynamics in Breast Cancer Brain Metastasis
08:23
Representative Results
In vitro
and
In vivo
Bioluminescence Assays
10:35
Conclusion
Summary
Automatic Translation
English (Original)
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français (French)
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Automatic Translation
缺氧诱导因子-1α活动的生物发光成像是用于监测在乳腺癌脑转移瘤小鼠模型的颅内肿瘤缺氧发展。
Tags
In Vivo Bioluminescence Imaging
Tumor Hypoxia Dynamics
Breast Cancer Brain Metastasis
Mouse Model
Malignant Progression
Therapeutic Response
Intracranial Development
Orthotopic Tumors
Bioluminescence Imaging (BLI)
Luciferase Gene Expression
Cancer Research
Tumor Growth
Treatment Response
Reporter Gene
Hypoxia Inducible Factor-1α (HIF-1α)
Gene Transcription
MDA-MB231 Cells
HIF-1α Bioluminescence Assay
Hypoxic Chamber
Photon Flux
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