Time-lapse imaging is used to assess behavior of primary preneoplastic mammary epithelial cells derived from genetically engineered mouse models of breast cancer risk to determine if there are correlations between specific behavioral parameters and distinct genetic lesions.
Nakles, R. E., Millman, S. L., Cabrera, M. C., Johnson, P., Mueller, S., Hoppe, P. S., Schroeder, T., Furth, P. A. Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer. J. Vis. Exp. (72), e50198, doi:10.3791/50198 (2013).