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JoVE Journal Bioengineering
Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers
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Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers

Article DOI: 10.3791/3520 • 10:08 min • July 25th, 2012
July 25th, 2012 •
1, 1, 1
1Department of Chemical Engineering, Stanford University

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In this article we describe the use of magnetic tweezers to study the effect of force on enzymatic proteolysis at the single molecule level in a highly parallelizable manner.

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Multiplexed Single-molecule Force Proteolysis Measurements Magnetic Tweezers Generation Detection Mechanical Forces Cell Physiology Cancer Metastasis Atherogenesis Wound Healing Extracellular Matrix (ECM) Enzymatically Remodel Forces On ECM Biological Importance Medical Importance Single Molecule Techniques Optical Trapping Atomic Force Microscopy Magnetic Tweezers (MT) Low Cost High Throughput PN (piconewton) Millisecond Temporal Resolution Enzyme Mechanism Highly Parallelizable Assay Trimeric Collagen Peptide Matrix Metalloproteinase 1 (MMP-1) Substrates And Proteases
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