In this article we describe the use of magnetic tweezers to study the effect of force on enzymatic proteolysis at the single molecule level in a highly parallelizable manner.
Adhikari, A. S., Chai, J., Dunn, A. R. Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers. J. Vis. Exp. (65), e3520, doi:10.3791/3520 (2012).