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2血管闭塞/低血压：全脑缺血模型大鼠

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Medicine

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JoVE Journal Medicine

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

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2血管闭塞/低血压：全脑缺血模型大鼠

DOI:

10.3791/50173-v

•

09:29 min

•

June 22, 2013

•

Thomas H. Sanderson^2,3, Joseph M. Wider³

¹Department of Emergency Medicine,Wayne State University School of Medicine, ²Cardiovascular Research Institute,Wayne State University School of Medicine, ³Department of Physiology,Wayne State University School of Medicine

Chapters

00:05Title
01:12Set-up and Surgical Preparation
02:44Surgical Procedures
04:41Ischemia Protocol
06:41Sample Collection and Analysis
07:51Results: Neuronal Changes after Ischemia
08:55Conclusion

Summary

Automatic Translation

双侧颈动脉闭塞，加上全身性低血压生产全脑缺血大鼠海马损坏，导致重复性严重。受试动物损害与脑损伤预测的模式，它们方便地恢复率和死亡率相对较低。

Tags

Keywords: 2-vessel Occlusion Global Brain Ischemia Cardiac Arrest Hippocampal Neurons CA1 Region Ischemia/reperfusion Brain Damage Cell Death Quantification ImageJ Model

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