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A “Patient-Like” Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
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JoVE Journal Medicine
A “Patient-Like” Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

A “Patient-Like” Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

DOI:
10.3791/52858-v

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05:06 min

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October 24, 2015

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, , , ,
1Department of Biological Sciences,Hunter College of the City University of New York, 2Departments of Biology and Biochemistry,The Graduate Center of the City University of New York

Chapters

  • 00:05Title
  • 01:12Orthotopic Hepatocyte Implantation
  • 03:45Results: Gross Examination of Primary Hepatocellular Carcinoma and Metastasis
  • 04:41Conclusion

Summary

Automatic Translation

Automatic Translation

The metastatic spread of cancer is the major cause of cancer-related deaths. We provide an in-depth description of our survival surgery methodology for establishing a “patient-like” orthotopic syngeneic mouse model system for studying the mechanisms of metastasis in solid organ tumors.

Tags

Hepatocellular CarcinomaMetastasisAnimal ModelSyngeneicOrthotopicBALB/cBNL 1ME A.7R.1 Cell LineLiver Cancer

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