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Desarrollo de un modelo basado en la rata alfa-sinucleína para la enfermedad de Parkinson mediante inyección estereotáctica de un vector viral adeno-asociado recombinante
JoVE Journal
Medicine
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JoVE Journal Medicine
Development of an Alpha-synuclein Based Rat Model for Parkinson’s Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
DOI:

08:33 min

February 28, 2016

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Chapters

  • 00:05Title
  • 01:11Stereotactic Injection of rAAV-α-SYN into the Rat Substantia Nigra
  • 05:18Results: Neurodegeneration Induced by rAAV2/7 α-SYN
  • 07:30Conclusion

Summary

Automatic Translation

This manuscript describes how viral vector-mediated local gene delivery provides an attractive way to express transgenes in the central nervous system. The protocol outlines all crucial steps to perform a viral vector injection in the substantia nigra of the rat to develop a viral vector-based animal model for Parkinson's disease.

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