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Cefoperazon behandlet musemodel af klinisk relevant<em> Clostridium difficile</em> Strain R20291
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
DOI:

06:51 min

December 10, 2016

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Chapters

  • 00:05Title
  • 00:53Inoculation of Mice with Clostridium difficile
  • 03:22Enumeration of C. difficile from Mouse Fecal Content
  • 05:03Results: The Murine Model of C. difficile Infection Demonstrates Significant Weight Loss, Bacterial Colonization and Histopathological Changes in Infected Mice
  • 06:10Conclusion

Summary

Automatic Translation

Denne protokol beskriver cefoperazon musemodel for Clostridium difficile infektion (CDI) ved anvendelse af en klinisk relevant og genetisk-tractable stamme, R20291. Fokus på klinisk sygdom overvågning, C. difficile bakteriel optælling, toksin cytotoksicitet, og histopatologiske ændringer i hele CDI i en musemodel er beskrevet i protokollen.

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