02:49CYP Activity Quantification in Cell Cultures: Metabolic Probes, Inducers, and Inhibitors
04:30CYP Activity Quantification in Cell Cultures: Medium Treatment
05:40CYP Activity Quantification in Cell Cultures: Mass Spectrometry (MS)-based Quantification
06:49CYP Activity Quantification in Cell Cultures: Probes Using Luminescence-based Methods
08:10Results: Quantification of Metabolites Produced by tha Activity of CYP Enzymes Following Cell Incubation with CYP Inducers, Substrates, and Inhibitors
Metabolisk kompetence in vitro systemer er en afgørende forudsætning for biotransformation og disposition af narkotika og giftstoffer. I denne protokol, beskriver vi anvendelsen af reference- metaboliske prober til at vurdere Fase I metabolismen i cellekulturer.