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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
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1NUS Nanoscience and Nanotechnology Initiative,National University of Singapore, 2Cardiovascular Research Institute, Yong Loo Lin School of Medicine,National University of Singapore, 3Department of Electrical and Computer Engineering,National University of Singapore, 4Institute of Materials Research Engineering,A*STAR (Agency for Science, Technology and Research)
Chapters
- 00:05Title
- 00:44Fabrication of the Sensor and Acquisition of the Data
- 03:31Sensor Bulk Sensitivity Test and Sensor Surface Modification
- 05:34Cardiac Troponin I (cTnI) Assay
- 06:48Results: cTnI Assay
- 07:56Conclusion
This work describes a nanoimprinting lithography method to fabricate high-quality sensing arrays that work on the principle of extraordinary optical transmission. The biosensor is low-cost, robust, easy to use, and can detect cardiac troponin I in serum at clinically relevant concentrations (99th percentile cutoff ∼10-400 pg/mL, depending on the assay).
