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Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
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Immunology and Infection
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JoVE Journal Immunology and Infection
Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

DOI:
10.3791/57658-v

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07:26 min

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July 01, 2018

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, , , , , ,
1College of Veterinary Medicine,Nanjing Agricultural University, 2Key Lab of Animal Bacteriology,Ministry of Agriculture, 3OIE Reference Lab for Swine Streptococcosis, 4School of Medicine,Tsinghua University, 5Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses

Chapters

  • 00:04Title
  • 00:46Preparation of Bacteria
  • 02:50Detecting the mRNA Expression of TLR2 and Cytokines in Brain Tissue
  • 05:30Results: S. suis Biofilms Contribute to Induction of Meningitis
  • 06:51Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we describe the intracranial subarachnoidal route of infection in mice to study roles of biofilms in Streptococcus suis meningitis. This infection model is also suitable for studying the pathogenesis of other bacterial meningitis and the efficacy of new drugs against bacterial meningitis.

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Keywords: Streptococcus SuisBiofilmsMeningitisMouse Infection ModelIntracranial Subarachnoidal InfectionPlanktonic CellsBiofilm State CellsRNA Extraction

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