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同位素稀释-高效液相色谱-抗生素在危重症患者中的多重治疗药物监测
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Please note that all translations are automatically generated.
Click here for the English version.
同位素稀释-高效液相色谱-抗生素在危重症患者中的多重治疗药物监测
DOI:
10.3791/58148-v
•
11:17 min
•
August 30, 2018
•
Carina Schuster
,
Sebastian Sterz
,
Daniel Teupser
,
Mathias Brügel
,
Michael Vogeser
,
Michael Paal
1
Institute of Laboratory Medicine, University Hospital
,
LMU Munich
Chapters
00:04
Title
01:05
Preparation of the Calibrators, Quality Control Samples, and Internal Standards Mix
02:29
Buffer Preparation for Chromatography
03:47
Sample Cleanup and HPLC-MS/MS Analysis
06:28
Quality Assessment and Quantification
08:14
Results: Data Analysis and Quantification of Piperacillin
09:44
Conclusion
Summary
Automatic Translation
English (Original)
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在此, 我们提出了一种基于串联质谱的协议, 用于定量治疗重症监护病房中的常用抗生素, 即头孢吡肟、美罗培南、环丙沙星、莫西沙星、利奈和哌拉西林。
Tags
Antibiotics
Therapeutic Drug Monitoring
Mass Spectrometry
HPLC-MS/MS
Intensive Care
Cefepime
Meropenem
Ciprofloxacin
Moxifloxacin
Linezolid
Piperacillin
Pharmacokinetics
Serum Calibrators
Quality Controls
Internal Standards
Mobile Phase
Formic Acid
Ammonium Formate
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