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JoVE Journal Cancer Research
Onderdrukking van Multiple Myeloma celgroei In Vivo door Single-muur koolstof nanobuis (SWCNT)-MALAT1 Antisense Oligos geleverd
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Onderdrukking van Multiple Myeloma celgroei In Vivo door Single-muur koolstof nanobuis (SWCNT)-MALAT1 Antisense Oligos geleverd

Article DOI: 10.3791/58598-v • 07:24 min • December 13th, 2018
December 13th, 2018 •
*1,2, *1, 1
1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
* These authors contributed equally

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Dit manuscript beschrijft de synthese van een single-muur koolstof nanobuis (SWCNT)-geconjugeerd MALAT1 antisense gapmer DNA oligonucleotide (SWCNT-anti-MALAT1), waaruit blijkt hoe de betrouwbare levering van de SWCNT en het krachtige therapeutische effect van anti-MALAT1 in vitro en in vivo. Methoden voor synthese, wijziging, conjugatie, en injectie van SWCNT-anti-MALAT1 worden beschreven.

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Kankeronderzoek kwestie 142 Single-muur koolstof nanobuis SWCNT multipel myeloom MALAT1 lang niet-coderende RNA lncRNA
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